Frequency domains of resting state default mode network activity in schizophrenia.

نویسندگان

  • Gianluca Mingoia
  • Kerstin Langbein
  • Maren Dietzek
  • Gerd Wagner
  • Stefan Smesny
  • Sigrid Scherpiet
  • Raka Maitra
  • Jürgen R Reichenbach
  • Ralf G M Schlösser
  • Christian Gaser
  • Heinrich Sauer
  • Igor Nenadic
چکیده

Probabilistic independent component analysis was applied to identify the default mode network (DMN) in resting state data obtained with functional magnetic resonance imaging from 25 DSM-IV schizophrenia and 25 matched healthy subjects. Power spectrum analysis showed a significant diagnosis × frequency interaction and higher power in one frequency band, indicating an alteration of DMN frequency spectrum in schizophrenia.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Increased Amplitude of Low Frequency Fluctuations but Normal Hippocampal-Default Mode Network Connectivity in Schizophrenia

BACKGROUND Clinical and preclinical studies have established that the hippocampus is hyperactive in schizophrenia, making it a possible biomarker for drug development. Increased hippocampal connectivity, which can be studied conveniently with resting state imaging, has been proposed as a readily accessible corollary of hippocampal hyperactivity. Here, we tested the hypothesis that hippocampal a...

متن کامل

How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations.

While several hypotheses about the neural mechanisms underlying auditory verbal hallucinations (AVH) have been suggested, the exact role of the recently highlighted intrinsic resting state activity of the brain remains unclear. Based on recent findings, we therefore developed what we call the 'resting state hypotheses' of AVH. Our hypothesis suggest that AVH may be traced back to abnormally ele...

متن کامل

Default-mode network dysfunction and self-referential processing in healthy siblings of schizophrenia patients

The default-mode network (DMN) of the brain shows highly coherent intrinsic activity in healthy subjects and is implicated in self-referential processing important for social cognitive functioning. Schizophrenia patients show abnormal resting-state connectivity within the DMN and this aberrant connectivity is thought to contribute to difficulties in self-referential and introspective processing...

متن کامل

Default mode network activity in schizophrenia studied at resting state using probabilistic ICA.

Alterations in brain function in schizophrenia and other neuropsychiatric disorders are evident not only during specific cognitive challenges, but also from functional MRI data obtained during a resting state. Here we apply probabilistic independent component analysis (pICA) to resting state fMRI series in 25 schizophrenia patients and 25 matched healthy controls. We use an automated algorithm ...

متن کامل

Integration of the Existed Knowledge on DMN: A Critical Review Study

The default-mode network (DMN) is one of the human brain’s networks activated in resting and self-referential thinking states. The nature of this network and its normal or abnormal changes has been the subject of various studies. The aim of this study was to systematical review and integrating the findings of that studies focused on the relationship of DMN with mental disorders and aging-induce...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Psychiatry research

دوره 214 1  شماره 

صفحات  -

تاریخ انتشار 2013